TRANSFORMATIONS OF 4-ARYLPYRROLO[1,2-<i>a</i>][1,4]BENZODIAZEPINES IN THREE-COMPONENT REACTIONS WITH ACTIVATED ALKYNES AND СН, NH, SH, AND ОН ACIDS

Authors

  • Леонид Г. Воскресенский People's Friendship University of Russia
  • Татьяна Н. Борисова People's Friendship University of Russia
  • Марьяна И. Бабаханова People's Friendship University of Russia
  • Татьяна М. Червякова People's Friendship University of Russia
  • Александр А. Титов People's Friendship University of Russia
  • Роман А. Новиков N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
  • Флавьен Тозе University of Douala
  • Ти Туйет Aнь Данг Chemistry Institute, Vietnam Academy of Science and Technology
  • Алексей В. Варламов People's Friendship University of Russia

DOI:

https://doi.org/10.1007/2513

Keywords:

acetylacetylene, СН acids, NH acids, ОН acids, SH acids, methyl propiolate, pyrrolo[1, 2-а][1, 6]benzodiazonine, cleavage of pyrrolo[1, 2-a][1, 4]benzodiazepines

Abstract

Three-component reactions of tetrahydropyrrolo[1,2-a][1,4]benzodiazepines with methyl propiolate or acetylacetylene and СН, NH, SH, and ОН acids were studied in various solvents. The reaction direction is assumed to depend on the nucleophilicity of anion, formed through deprotonation of acid by the anionic center of initial Michael-type zwitterion.

How to Cite
Voskressensky, L. G.; Borisova, T. N.; Babakhanova, M. I.; Chervyakova, T. M.; Titov, A. A.; Novikov, R. A.; Toze, F.; Ti Tuyet Anh Dang, Varlamov, A. V. Chem. Heterocycl. Compd. 2015, 51, 639. [Khim. Geterotsikl. Soedin. 2015, 51, 639.]

For this article in the English edition see DOI 10.1007/s10593-015-1751-0

Author Biography

Леонид Г. Воскресенский, People's Friendship University of Russia

Organic Chemistry Department, professor

Downloads

Published

2015-07-17

Issue

Vol. 51 No. 7 (2015)

Section

Original Papers