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TRANSFORMATIONS OF 4-ARYLPYRROLO[1,2-a][1,4]BENZODIAZEPINES IN THREE-COMPONENT REACTIONS WITH ACTIVATED ALKYNES AND СН, NH, SH, AND ОН ACIDS

Леонид Г. Воскресенский, Татьяна Н. Борисова, Марьяна И. Бабаханова, Татьяна М. Червякова, Александр А. Титов, Роман А. Новиков, Флавьен Тозе, Ти Туйет Aнь Данг, Алексей В. Варламов
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Abstract


Three-component reactions of tetrahydropyrrolo[1,2-a][1,4]benzodiazepines with methyl propiolate or acetylacetylene and СН, NH, SH, and ОН acids were studied in various solvents. The reaction direction is assumed to depend on the nucleophilicity of anion, formed through deprotonation of acid by the anionic center of initial Michael-type zwitterion.

How to Cite
Voskressensky, L. G.; Borisova, T. N.; Babakhanova, M. I.; Chervyakova, T. M.; Titov, A. A.; Novikov, R. A.; Toze, F.; Ti Tuyet Anh Dang, Varlamov, A. V. Chem. Heterocycl. Compd. 2015, 51, 639. [Khim. Geterotsikl. Soedin. 2015, 51, 639.]

For this article in the English edition see DOI 10.1007/s10593-015-1751-0


Keywords


acetylacetylene, СН acids, NH acids, ОН acids, SH acids, methyl propiolate, pyrrolo[1,2-а][1,6]benzodiazonine, cleavage of pyrrolo[1,2-a][1,4]benzodiazepines

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