SYNTHESIS, CHARACTERIZATION, AND ANTIBACTERIAL EVALUATION OF NEW ALKYL 2-AMINO-4-ARYL-4<i>H</i>-CHROMENE-3-CARBOXYLATES

Authors

  • Sedighe Gholipour Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad 91735-413
  • Abolghasem Davoodnia Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad 91735-413
  • Mahboobeh Nakhaei-Moghaddam Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad 91735-413

DOI:

https://doi.org/10.1007/2621

Keywords:

alkyl 2-amino-4-aryl-4H-chromene-3-carboxylates, ethyl cyanoacetate, methyl cyanoacetate, sodium carbonate, antibacterial activity, cyclocondensation

Abstract

A series of alkyl 2-amino-4-aryl-4H-chromene-3-carboxylates was synthesized by an efficient, solvent-free one-pot three-component cyclocondensation of resorcinol, aromatic aldehydes, and ethyl or methyl cyanoacetate using sodium carbonate as catalyst. The present methodology offers several advantages, such as a simple procedure with ease of handling, short reaction time, high yields, and the absence of any volatile and hazardous organic solvents. The products were characterized on the basis of IR, 1H NMR, and 13C NMR spectral and microanalytical data and evaluated for their antibacterial activity against Gram-positive bacteria (Staphylococcus epidermidis and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli) using paper disc diffusion technique.

How to Cite
Gholipour, S.; Davoodnia, A.; Nakhaei-Moghaddam, M. Chem. Heterocycl. Compd. 2015, 51, 808. [Khim. Geterotsikl. Soedin. 2015, 51, 808.]

For this article in the English edition see DOI 10.1007/s10593-015-1779-1

Author Biographies

Abolghasem Davoodnia, Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad 91735-413

Department of Chemistry

Mahboobeh Nakhaei-Moghaddam, Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad 91735-413

Department of Biology

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Published

2015-10-13

Issue

Vol. 51 No. 9 (2015)

Section

Original Papers