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GREEN AND CATALYST-FREE ONE-POT SYNTHESIS OF 2,3-DIHYDROQUINAZOLIN-4(1H)-ONES IN WATER

Abolfazl Olyaei, Fatemeh Rahbarian, Mahdieh Sadeghpour
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Abstract


A facile and highly efficient protocol was successfully applied to synthesize mono- and disubstituted dihydroquinazolinones through a three-component coupling reaction of isatoic anhydride, aniline or ammonium acetate, and aromatic aldehydes in refluxing water with excellent yield without using any catalysts. The protocol avoids the use of hazardous solvents and chromatographic separation. The generality and functional tolerance of this convergent and environmentally benign method is demonstrated.

How to Cite
Olyaei, A.; Rahbarian, F.; Sadeghpour, M. Chem. Heterocycl. Compd. 2015, 51, 899. [Khim. Geterotsikl. Soedin. 2015, 51, 899.]

For this article in the English edition see DOI 10.1007/s10593-015-1793-3


Keywords


isatoic anhydride; aromatic aldehyde; dihydroquinazolinone

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