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A NOVEL SYNTHESIS OF (E)-1-(2-HYDROXYPHENYL)-3-(1Н-INDOL-3-YL)-PROP-2-EN-1-ONES FROM CHROMONE-3-CARBOXYLIC ACID AND INDOLES

Михаил Ю. Корнев, Владимир С. Мошкин, Вячеслав Я. Сосновских
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Abstract


The reaction of chromone-3-carboxylic acid with indoles in boiling ethanol proceeds as a 1,4-nucleophilic addition with successive opening of the pyrone ring and decarboxylation to afford a series of previously unknown trans-indolyl chalcones in 27–60% yields.

How to Cite
Kornev, M. Yu.; Moshkin, V. S.; Sosnovskikh, V. Ya. Chem. Heterocycl. Compd. 2015, 51, 858. [Khim. Geterotsikl. Soedin. 2015, 51, 858.]

For this article in the English edition see DOI 10.1007/s10593-015-1786-2


Keywords


chromone-3-carboxylic acid; indolyl chalcones; indoles; Michael addition

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