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ALKYLATION OF 5-ARYLTETRAZOLES WITH 2- AND 4-HYDROXYBENZYL ALCOHOLS

Виталий А. Осянин, Дмитрий В. Осипов, Виталий Ю. Накушнов, Маргарита Н. Земцова, Юрий Н. Климочкин
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Abstract


The reaction of salicylic alcohol with 5-aryltetrazoles gave mixtures of 2-[(5-aryl-1H-tetrazol-1-yl)methyl]- and 2-[(5-aryl-2H-tetrazol-2yl)methyl]phenols. In the case of other ortho- and para-hydroxybenzyl alcohols, 2,5-disubstituted products were formed selectively. The criteria for detecting 1,5- and 2,5-disubstituted N-benzyltetrazoles by standard 1Н and 13С NMR spectroscopy have been identified.

How to Cite
Osyanin, V. A.; Osipov, D. V.; Nakushnov, V. Yu.; Zemtsova, M. N.; Klimochkin, Yu. N. Chem. Heterocycl. Compd. 2015, 51, 984. [Khim. Geterotsikl. Soedin. 2015, 51, 984.]

For this article in the English edition see DOI 10.1007/s10593-016-1808-8

 


Keywords


5-aryltetrazoles; ortho-hydroxybenzyl alcohols; ortho-quinone methides; para-hydroxybenzyl alcohols; tetrazolylmethylphenols; aza-Michael reaction; hydroxybenzylation

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