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STRUCTURAL ANALOGS OF UMIFENOVIR 2*. THE SYNTHESIS AND ANTIHIV ACTIVITY STUDY OF NEW REGIOISOMERIC (trans-2-PHENYLCYCLOPROPYL)-1Н-INDOLE DERIVATIVES

Доминик Шольц, Евсей А. Ручко, Сергей Н. Лавренов, Вадим В. Качала, Максим Б. Навроцкий, Александр С. Бабушкин
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Abstract


We report new carboanalogs of umifenovir – regioisomeric derivatives of ethyl 5-hydroxy-(trans-2-phenylcyclopropyl)-1Н-indole-3carboxylate. The inhibition of HIV replication by umifenovir and its carboanalogs at micromolar concentration range has been demonstrated for the first time.

How to Cite
Schols, D.; Ruchko, E. A.; Lavrenov, S. N.; Kachala, V. V.; Nawrozkij, M. B.; Babushkin, A. S. Chem. Heterocycl. Compd. 2015, 51, 978. [Khim. Geterotsikl. Soedin. 2015, 51, 978.]

For this article in the English edition see DOI 10.1007/s10593-016-1807-9

 


Keywords


umifenovir; conformationally restricted analogs; antiviral activity

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