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SYNTHESIS AND ANTIRADICAL ACTIVITY OF 4-ARYL(HETARYL)-SUBSTITUTED 3-AMINOPYRIDIN-2(1Н)-ONES

Иван В. Кулаков, Мария В. Мацукевич, Зарина Т. Шульгау, Шынгыс Сергазы, Тулеген М. Сейлханов, Амрит Пузари, Александр Семенович Фисюк
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Abstract


The reaction of aryl(hetaryl)-substituted 1,3-diketones with chloroacetamide gave the respective N-(3-oxoalkenyl)chloroacetamides, which were converted to 3-pyridinium-substituted pyridin-2(1Н)-ones upon heating with excess of pyridine in n-butanol. The decomposition of pyridinium salts with hydrazine hydrate resulted in new 4-aryl(hetaryl)-substituted 3-aminopyridin-2(1Н)-ones, which showed strong antiradical activity with respect to ABTS and DPPH radicals.

How to Cite
Kulakov, I. V.; Matsukevich, M. V.; Shulgau, Z. T.; Sergazy, Sh.; Seilkhanov, T. M.; Puzari, A.; Fisyuk, A. S. Chem. Heterocycl. Compd. 2015, 51, 991. [Khim. Geterotsikl. Soedin. 2015, 51, 991.]

For this article in the English edition see DOI 10.1007/s10593-016-1809-7


Keywords


3-aminopyridin-2(1Н)-ones; 1,3-diketones; N-(3-oxoalkenyl)chloroacetamides; antiradical activity; intramolecular cyclization

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