Open Access Open Access  Restricted Access Subscription Access

NOVEL PALLADIUM-CATALYZED DOMINO REACTION OF 2-METHYLINDOLES WITH 2-IODOBENZYL BROMIDE

Edgars Abele, Sergey Belyakov, Tatyana Beresneva, Lena Golomba, Ramona Abele
Cover Image

Abstract


A novel palladium-catalyzed domino reaction of 2-methylindoles with 2-iodobenzyl bromide in the system Pd(OAc)2/Xantphos/t-BuOK/PhMe leading to indole-fused tricyclo[7,3,1,02,7]trideca-2(7),3,5-triene ring system is presented. Pd-catalyzed reaction of 2-methylindole with 5-bromo-6-bromomethylbenzo[1,3]dioxole afforded 3,3-bis(6-bromobenzo[1,3]dioxol-5-ylmethyl)-2-methyl-3H-indole.

How to Cite
Abele, E.; Belyakov, S.; Beresneva, T.; Golomba, L.; Abele, R. Chem. Heterocycl. Compd. 2016, 52, 140. [Khim. Geterotsikl. Soedin. 2016, 52, 140.]

For this article in the English edition see DOI 10.1007/s10593-016-1846-2

 


Keywords


2-iodobenzyl bromide; 2-methylindole; potassium t-butoxide; tricyclo[7,3,1,02,7]trideca-2(7),3,5-trienes; palladium catalysis

Full Text: PDF Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv