SYNTHESIS OF ISOTHIOCOUMARIN DERIVATIVES

Authors

  • Н. Т. Походыло Ivan Franko National University of Lviv
  • В. С. Матийчук Ivan Franko National University of Lviv
  • Н. Д. Обушак Ivan Franko National University of Lviv

DOI:

https://doi.org/10.1007/2796

Keywords:

2-benzofuran-1(3H)-one, 1-oxo-1H-isothiochromenone, 2-formylbenzoic acid, heterocyclization, recyclization

Abstract

A method was developed for the synthesis of 1-oxo-1H-isothiochromenes from 2-benzofuran-1(3H)-one (phthalide). 3-Bromo-6-chloro- and 3,6-dibromo-2-benzofuran-1(3H)-ones were prepared by the bromination of 6-chloro- and 6-bromo-2-benzofuran-1(3H)-ones and were converted by hydrolysis into 5-chloro- or 5-bromo-2-formylbenzoic acids. The condensation of these acids with rhodanine followed by recyclization gave 7-chloro- and 7-bromo-1-oxo-1H-isothiochromene-3-carboxylic acids.

How to Cite
Pokhodylo, N. T.; Matiychuk, V. S.; Obushak, M. D. Chem. Heterocycl. Compd. 2010, 46, 140. [Khim. Geterotsikl. Soedin. 2010, 173.]

For this article in the English edition see DOI 10.1007/s10593-010-0484-3

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Published

2015-11-26

Issue

No. 2 (2010)

Section

Original Papers