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NEW N-MANNICH BASES OBTAINED FROM ISATIN AND PIPERAZINE DERIVATIVES: THE SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY

Андрей В. Богданов, Альбина М. Вазыхова, Надежда Р. Хасиятуллина, Дмитрий Б. Криволапов, Алексей Б. Добрынин, Александра Д. Волошина, Владимир Ф. Миронов
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Abstract


A Mannich reaction of isatin with monosubstituted piperazines in the presence of aqueous formaldehyde was used to synthesize new, as well as two previously described derivatives of 1-piperazinomethylisatins, which were further converted to isoindigo derivatives. The antimicrobial activity of the obtained heterocycles was evaluated.

How to Cite
Bogdanov, A. V.; Vazykhova, A. M.; Khasiyatullina, N. R.; Krivolapov, D. B.; Dobrynin, A. B.; Voloshina, A. D.; Mironov, V. F. Chem. Heterocycl. Compd. 2016, 52, 25. [Khim. Geterotsikl. Soedin. 2016, 52, 25.]

For this article in the English edition see DOI 10.1007/s10593-016-1826-6


Keywords


isatin; piperazines; aminomethylation; antimicrobial activity; Mannich reaction

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