NEW N-MANNICH BASES OBTAINED FROM ISATIN AND PIPERAZINE DERIVATIVES: THE SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY

Authors

  • Андрей В. Богданов A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
  • Альбина М. Вазыхова A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
  • Надежда Р. Хасиятуллина A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
  • Дмитрий Б. Криволапов A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
  • Алексей Б. Добрынин A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
  • Александра Д. Волошина A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences
  • Владимир Ф. Миронов A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences

DOI:

https://doi.org/10.1007/2819

Keywords:

isatin, piperazines, aminomethylation, antimicrobial activity, Mannich reaction

Abstract

A Mannich reaction of isatin with monosubstituted piperazines in the presence of aqueous formaldehyde was used to synthesize new, as well as two previously described derivatives of 1-piperazinomethylisatins, which were further converted to isoindigo derivatives. The antimicrobial activity of the obtained heterocycles was evaluated.

How to Cite
Bogdanov, A. V.; Vazykhova, A. M.; Khasiyatullina, N. R.; Krivolapov, D. B.; Dobrynin, A. B.; Voloshina, A. D.; Mironov, V. F. Chem. Heterocycl. Compd. 2016, 52, 25. [Khim. Geterotsikl. Soedin. 2016, 52, 25.]

For this article in the English edition see DOI 10.1007/s10593-016-1826-6

Author Biography

Андрей В. Богданов, A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences

Андрей Владимирович Богданов

Лаборатория фосфорсодержащих аналогов природных соединений, с. н. с., к. х. н.

http://www.iopc.knc.ru/content/богданов-андрей-владимирович

 

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Published

2016-02-08

Issue

Vol. 52 No. 1 (2016)

Section

Original Papers