Open Access Open Access  Restricted Access Subscription Access

SYNTHESIS OF N-HETEROARYLAMIDINES OF 1,2,3-THIADIAZOLE-4-CARBOXYLIC ACID FROM 2-CYANOTHIOACETAMIDES AND 5-AZIDO-1-METHYL-4-NITROIMIDAZOLE

Николай А. Беляев, Татьяна В. Березкина, Василий А. Бакулев
Cover Image

Abstract


The reaction of 2-cyanothioacetamides with 5-azido-1-methyl-4-nitroimidazole in ethanol in the presence of sodium ethoxide at 0°С lead to the formation of previously unknown N-heteroarylamidines of 1,2,3-thiadiazole-4-carboxylic acid in 58–76% yields.

How to Cite
Belyaev, N. A.; Beryozkina, T. V.; Bakulev, V. A. Chem. Heterocycl. Compd. 2016, 52, 206. [Khim. Geterotsikl. Soedin. 2016, 52, 206.]

For this article in the English edition see DOI 10.1007/s10593-016-1861-3


Keywords


azides; cyanothioacetamides; imidazoles; 1,2,3-thiadiazoles; thioamides; 1,2,3-triazoles; Cornforth rearrangement

Full Text: PDF (Russian) Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv