SYNTHESIS OF SOME FUSED HETEROCYCLES BASED ON THIENO[2,3-<i>b</i>]PYRIDINE AND THEIR ANTIMICROBIAL ACTIVITY

Authors

  • F. A. El-Essawy Chemistry Department, Faculty of Science, Shebin El-Koam
  • M. A. Hawatta Chemistry Department, Faculty of Science, Shebin El-Koam
  • A. E.-S. Abdel-Megied Chemistry Department, Faculty of Science, Shebin El-Koam
  • D. A. El-Sherbeny Chemistry Department, Faculty of Science, Shebin El-Koam

DOI:

https://doi.org/10.1007/2838

Keywords:

imidazole, pyridothienopyrimidine, 1, 2, 3, 4-tetrazoles, 4-triazoles, antibacterial, antifungal activity, cyclocondensation

Abstract

The reaction of 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carbonitrile with ethylenediamine  in  the presence of a  catalytic  amount  of carbon  disulfide  afforded 2-(4,5-dihydro-1H-imidazol-2-yl)-4,6-dimethylthieno[2,3-b]pyridine-3-amine while its reaction with triethyl orthoformate followed by the reaction with hydrazine hydrate gave 4-imino-7,9-dimethylpyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-amine. These two derivatives underwent cyclocondensation reactions with commercially available reactants to afford new heterocycles containing thieno[2,3-b]pyridine moiety. Some of the synthesized derivatives were tested for antimicrobial and antifungal activity.

How to Cite
El-Essawy, F. A.; Hawatta, M. A.; Abdel-Megied, A. E.-S.; El-Sherbeny, D. A. Chem. Heterocycl. Compd. 2010, 46, 325. [Khim. Geterotsikl. Soedin. 2010, 415.]

For this article in the English edition see DOI 10.1007/s10593-010-0508-z

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Published

2015-12-03

Issue

No. 3 (2010)

Section

Original Papers