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SYNTHESIS OF INDAZOLOQUINAZOLINE SYSTEM

Selvaraj Mohana Roopan, Jeyakannu Palaniraja
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Abstract


Indazoloquinazolines are a class of heterocyclic compounds consisting of fused indazole and quinazoline fragments that can be connected with nitrogen atom as a fusion point. The tetracyclic scaffolds built that way include indazolo[2,3-c]quinazolines, indazolo[2,3-a]quinazolines, and indazolo[3,2-b]quinazolines. The natural occurrence of this compound class is rare, however, the indazolo-fused quinazolines possess a wide range of biological activities. Among those, indazolo[2,3-a]quinazolines have shown high antibacterial activity. The synthetic routes towards indazoloquinazolines can be categorised into several groups: 1) metal-catalyzed and metal-free intramolecular cyclizations; 2) metal-catalyzed and metal-free intermolecular reactions; 3) reductive intramolecular cyclization; 4) multicomponent assembly reactions.

How to Cite
Roopan, S. M.; Palaniraja, J. Chem. Heterocycl. Compd. 2016, 52, 93. [Khim. Geterotsikl. Soedin. 2016, 52, 93.]

For this article in the English edition see DOI 10.1007/s10593-016-1838-2


Keywords


indazolo[2,3-a]quinazolines; indazolo[2,3-c]quinazolines; indazolo[3,2-b]quinazolines

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