3-(HETARYLAMINO)- AND 3-[(HETARYLMETHYL)AMINO]ISOQUINOLIN-1(2H)-ONES

Abstract

The reaction of 2-(cyanomethyl)benzoic acid with amines RNH₂ (R = Ar, Het, CH₂Ar, CH₂Het) leads to the formation of the corresponding 3‑NHR‑isoquinolin‑1(2H)‑ones. When R = CH₂Ar and CH₂Het, there is a side reaction involving hydrolysis of the hydrolytically‑unstable intermediates, derivatives of 2‑(2‑amino‑2‑iminoethyl)benzoic acid, leading to 2‑R‑isoquinoline‑1,3(2H,4H)‑diones.

How to Cite
Potikha, L. M.; Gutsul, R. M.; Kovtunenko, V. A.; Tolmachev, A. A. Chem. Heterocycl. Compd. 2010, 46, 457. [Khim. Geterotsikl. Soedin. 2010, 575.]

For this article in the English edition see DOI 10.1007/s10593-010-0531-0