4-HYDROXY-2-QUINOLONES. 176. 4-R-2-OXO-1,2-DIHYDROQUINOLINE-3-CARBOXYLIC ACIDS. SYNTHESIS, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

Authors

  • И. В. Украинец National University of Pharmacy, Kharkiv 61002
  • А. А. Давиденко Винницкий национальный медицинский университет им. Н. И. Пирогова, Винница 21018
  • Е. В. Моспанова Институт химических технологий восточно-украинского национального университета им. Владимира Даля, Рубежное 93003
  • Л. В. Сидоренко National University of Pharmacy, Kharkiv 61002
  • Е. Н. Свечникова National University of Pharmacy, Kharkiv 61002

DOI:

https://doi.org/10.1007/2970

Keywords:

4-R-2-oxo-1, 2-dihydroquinoline-3-carboxylic acids, pKa, analgesic activity, hydrolysis

Abstract

We have carried out the synthesis and a comparative analysis of the acidic properties of a large group of 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids. Features of the recorded NMR spectra of these compounds are discussed together with their analgesic properties.

How to Cite
Ukrainets, I. V.; Davidenko, A. A.; Mospanova, E. V.; Sidorenko, L. V.; Svechnikova, E. N. Chem. Heterocycl. Compd. 2010, 46, 559. [Khim. Geterotsikl. Soedin. 2010, 706.]

For this article in the English edition see DOI 10.1007/s10593-010-0546-6

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Published

2016-01-15

Issue

No. 5 (2010)

Section

Original Papers