STUDY OF ACYLATION REACTIONS IN 3-AMINOCARBOSTYRIL DERIVATIVES

Authors

  • Л. М. Потиха Taras Shevchenko Kiev National University
  • Р. М. Гуцул "Ukrorgsintez"
  • В. А. Ковтуненко Taras Shevchenko Kiev National University
  • А. В. Туров Taras Shevchenko Kiev National University

DOI:

https://doi.org/10.1007/2971

Keywords:

1-aminocarbostyril, 3-amino-1-isoquinolinol, enamine, isoquinoline, acylation

Abstract

Acylation of 3-amino-1(2H)-isoquinolinone may proceed at three points – at the oxygen atom of the carbonyl group, at the nitrogen atom of the 3-amino group, and at the carbon atom in position 4 of the isoquinolinone fragment. Factors influencing the results of the reactions have been determined, and conditions have been found for the synthesis of three types of products – 4-(acyl)-3-(R-amino)-1(2H)-isoquinolinones, N-(1-oxo-1,2-dihydro-3-isoquinolinyl)-R-amides, and esters of 3-(R-amino)-1-iso-quinolinol.

How to Cite
Potikha, L. M.; Gutsul, R. M.; Kovtunenko, V. A.; Turov, A. V. Chem. Heterocycl. Compd. 2010, 46, 569. [Khim. Geterotsikl. Soedin. 2010, 718.]

For this article in the English edition see DOI 10.1007/s10593-010-0547-5

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Published

2016-01-15

Issue

No. 5 (2010)

Section

Original Papers