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FUNCTIONALIZED 2'-CARBOXAMIDODEOXYBENZOINS BY RING OPENING OF 3-ARYL-1H-ISOCHROMEN-1-ONES WITH SECONDARY AMINES

Olga V. Shablykina, Viktoriia S. Moskvina, Valentina V. Ishchenko, Eugeniia B. Valter, Volodymir P. Khilya
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Abstract


An efficient approach based on pyrone ring opening in 3-arylisocoumarins in the presence of cyclic secondary amines was developed in order to prepare amides of deoxybenzoin-2'-carboxylic acids, diverse functionalized structures useful for the synthesis of polyfunctional compounds.

 


Keywords


3-arylisocoumarins; 2'-carboxamidodeoxybenzoins; N-nucleophiles; amidation; ring opening

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv