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THREE-COMPONENT SYNTHESIS OF TETRASUBSTITUTED PYRROLES BY CONDENSATION WITH AMINES AND ARYLGLYOXALS

Надежда Н. Колос, Виктория В. Зубарь, Ирина В. Омельченко, Владимир И. Мусатов
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Abstract


A one-pot three-component condensation for the synthesis of functionalized pyrroles from arylglyoxal hydrates, acetylacetone or acetoacetic ester, and halo-substituted anilines has been developed. The reaction of ethyl 3-aminocrotonate and arylglyoxal led to the respective ethyl 5-aryl-4-hydroxy-2-methyl-1H-pyrrole-3-carboxylates.

Authors: Nadezhda N. Kolos, Viktoriya V. Zubar, Irina V. Omelchenko, Vladimir I. Musatov

 


Keywords


acetoacetic ester; acetylacetone; anilines; arylglyoxals; ethyl 3-aminobuten-2-oate; pyrroles; multicomponent reactions

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