THREE-COMPONENT SYNTHESIS OF TETRASUBSTITUTED PYRROLES BY CONDENSATION WITH AMINES AND ARYLGLYOXALS

Authors

  • Надежда Н. Колос Харьковский национальный университет им. В.Н. Каразина
  • Виктория В. Зубарь
  • Ирина В. Омельченко
  • Владимир И. Мусатов НТК ''Институт монокристаллов'' НАН Украины

DOI:

https://doi.org/10.1007/3092

Keywords:

acetoacetic ester, acetylacetone, anilines, arylglyoxals, ethyl 3-aminobuten-2-oate, pyrroles, multicomponent reactions

Abstract

A one-pot three-component condensation for the synthesis of functionalized pyrroles from arylglyoxal hydrates, acetylacetone or acetoacetic ester, and halo-substituted anilines has been developed. The reaction of ethyl 3-aminocrotonate and arylglyoxal led to the respective ethyl 5-aryl-4-hydroxy-2-methyl-1H-pyrrole-3-carboxylates.

Authors: Nadezhda N. Kolos, Viktoriya V. Zubar, Irina V. Omelchenko, Vladimir I. Musatov

 

Author Biography

Надежда Н. Колос, Харьковский национальный университет им. В.Н. Каразина

кафедра органической химии, профессор

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Published

2016-04-11

Issue

Vol. 52 No. 4 (2016)

Section

Original Papers