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TRANSFORMATIONS OF COTARNINE CHLORIDE BY THE ACTION OF SILVER ACETYLIDES AND ALKYNES

Леонид Г. Воскресенский, Александр А. Титов, Реза Самавати, Татьяна Н. Борисова, Елена А. Сорокина, Алексей В. Варламов
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Abstract


Three-component reactions of cotarnine chloride with silver acetylides and methyl propiolate or ethynyl methyl ketone in acetonitrile, as well as two-component reactions of 5-phenylethynyl-substituted tetrahydro[1,3]dioxolo[4,5-g]isoquinoline with alkynes in various solvents were studied. Performing them in 2,2,2-trifluoroethanol as the solvent, 10-phenylethynyl-substituted tetrahydro[1,3]dioxolo[4,5-i][3]benzazocines were obtained in good yields.

 

Authors: Leonid G. Voskressensky, Alexander A. Titov, Reza Samavati, Tatiana N. Borisova, Elena A. Sorokina, Alexey V. Varlamov


Keywords


cotarnine chloride; [1,3]dioxolo[4,5-i][3]benzazocines; [1,3]dioxolo[4,5-g]pyrrolo[2,1-a]isoquinolines; DMAD; ethynyl methyl ketone; methyl propiolate; silver acetylides.

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