SELENIUM ANALOGS OF RALOXIFENE: ANTIOXIDANT ACTIVITY ENDOWED TO AN OLD DRUG

Authors

  • Ilona Domracheva Latvian Institute of Organic Synthesis
  • Anita Gulbe Latvian Institute of Organic Synthesis
  • Edgars Paegle Latvian Institute of Organic Synthesis
  • Pavel Arsenyan Latvian Institute of Organic Synthesis

DOI:

https://doi.org/10.1007/3146

Keywords:

raloxifene, antioxidant, peroxyl radical, selenium, selenophene, superoxide radical

Abstract

The antioxidant activity of selenium-containing analogs of raloxifene was studied by the ability to scavenge 2,2-diphenyl-1-picrylhydrazyl, superoxide, nitric oxide, and peroxyl radicals. These compounds exhibited similar scavenging properties as resveratrol with respect to superoxide radical and had an impressive activity in peroxyl radical scavenging, making them promising candidates for the development of antioxidant agents.

Author Biographies

Ilona Domracheva, Latvian Institute of Organic Synthesis

Head of experimental chemotherapy group.

Anita Gulbe, Latvian Institute of Organic Synthesis

Research assistant.

Edgars Paegle, Latvian Institute of Organic Synthesis

Research assistant.

Pavel Arsenyan, Latvian Institute of Organic Synthesis

Head of research group.

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Published

2016-07-18

Issue

Vol. 52 No. 8 (2016)

Section

Original Papers