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SELENIUM ANALOGS OF RALOXIFENE: ANTIOXIDANT ACTIVITY ENDOWED TO AN OLD DRUG

Ilona Domracheva, Anita Gulbe, Edgars Paegle, Pavel Arsenyan
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Abstract


The antioxidant activity of selenium-containing analogs of raloxifene was studied by the ability to scavenge 2,2-diphenyl-1-picrylhydrazyl, superoxide, nitric oxide, and peroxyl radicals. These compounds exhibited similar scavenging properties as resveratrol with respect to superoxide radical and had an impressive activity in peroxyl radical scavenging, making them promising candidates for the development of antioxidant agents.


Keywords


raloxifene; antioxidant; peroxyl radical; selenium; selenophene; superoxide radical

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