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Fe3O4 NANOPARTICLES AS AN EFFICIENT AND REUSABLE CATALYST FOR THE SOLVENT‐FREE SYNTHESIS OF 1H-INDOLE AND 1H-PYRROLE DERIVATIVES

S. E. Babaei, Z. Hossaini, R. Ramezani Besheli, V. Tavakkoli
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Abstract


Magnetic Fe3O4 nanoparticles as a heterogeneous catalyst were found to be efficient for the synthesis of a series of pyrrole and indole derivatives using three-component reactions of primary amines, 1,3-dicarbonyl compounds, and activated acetylenic compounds under solvent-free conditions at room temperature. The present protocol offers the advantages of clean reaction, short reaction time, high yield, easy purification, and affordability of the catalyst.


Keywords


activated acetylenic compounds; ethyl 2-chloroacetoacetate; Fe3O4 nanoparticles; green synthesis

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