ROBUST SYNTHESIS OF LINEAR AND ANGULAR FUROQUINOLINES USING RAP–STOERMER REACTION

Authors

  • Devadoss K. Kumar PSG College of Arts and Science, Avinashi road, Civil Aerodrome post, Coimbatore-641014, Tamilnadu
  • Rayappan Rajkumar Bharathiar University, Coimbatore-641046, Tamilnadu
  • Subramaniam P. Rajendran Bharathiar University, Coimbatore-641046, Tamilnadu

DOI:

https://doi.org/10.1007/3181

Keywords:

3-acetyl-6-chloro-4-phenyl-1H-quinolin-2-one, 3-acetyl-4-hydroxy-1-methyl-1H-quinolin-2-one, angular furo[3, 2-c]quinolines, linear furo[2, 3-b]quinolines, Rap–Stoermer reaction

Abstract

We have synthesized novel linear and angular furoquinolines via the Rap–Stoermer reaction by conventional as well as microwave method that furnished an enhanced yield. Initially, we synthesized linear furo[2,3-b]quinolines from 3-acetyl-6-chloro-4-phenyl-1H-quinolin-2-one and three different α-halocarbonyl compounds: chloroacetophenone, ethyl chloroacetate, and chloroacetamide. The scope of the methodology was further extended to the synthesis of angular furo[3,2-c]quinolines by utilizing 3-acetyl-4-hydroxy-1methyl-1H-quinolin-2-one and α-halocarbonyl compounds.

 

Author Biographies

Devadoss K. Kumar, PSG College of Arts and Science, Avinashi road, Civil Aerodrome post, Coimbatore-641014, Tamilnadu

Devadoss Karthik Kumar

Assistant professor

Rayappan Rajkumar, Bharathiar University, Coimbatore-641046, Tamilnadu

Rayappan Rajkumar

Reasearch scholar

Subramaniam P. Rajendran, Bharathiar University, Coimbatore-641046, Tamilnadu

Subramaniam Parameswaran Rajendran

Professor, Department of chemistry

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Published

2016-06-09

Issue

Vol. 52 No. 5 (2016)

Section

Original Papers