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AN EFFICIENT SYNTHESIS OF (3-INDOLYL)ACETONITRILES BY REDUCTION OF HYDROXAMIC ACIDS

Александр B. Аксенов, Николай A. Аксенов, Зарема B. Джандигова, Инна В. Аксенова, Леонид Г. Воскресенский, Александр H. Смирнов, Михаил А. Рубин
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Abstract


A new, highly efficient method was developed for the synthesis of (3-indolyl)acetonitriles by reduction of readily available (3-indolyl)hydroxamic acids with phosphorus trichloride. The nitriles obtained according to this method are of significant interest for structure-activity studies of potential anticancer agents.

Authors: Alexander V. Aksenov*, Nicolai A. Aksenov, Zarema V. Dzhandigova, Inna V. Aksenova, Leonid G. Voskressensky, Alexander N. Smirnov, Michael A. Rubin*

 


Keywords


hydroxamic acids; indoles; nitriles; reduction

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