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SYNTHESIS AND STRUCTURE OF NOVEL YLIDENE DERIVATIVES OF METHANOBENZO[g]THIAZOLO[2,3-d][1,3,5]OXADIAZOCINE

Иван В. Кулаков, Диана Н. Огурцова, Зарина Т. Шульгау, Тулеген М. Сейлханов, Юрий В. Гатилов
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Abstract


Novel benzylidene and furylidene derivatives of tricyclic thiazolo[2,3-d][1,3,5]oxadiazocines were synthesized, and their structures were confirmed by 1H and 13C NMR spectroscopy. It was shown that ylidene derivatives of 11H-5,11,5-pentane-[1,1,5]triyl[1,3]thiazolo[2,3-d][1,3,5]oxadiazocin-1-one are obtained as a mixture of Z- and E-isomers. Recrystallization of the isomer mixture affords the major Z-isomer, structure of which has been established by X-ray structural analysis.

 

Authors: Ivan V. Kulakov, Diana N. Ogurtsova, Zarina T. Shulgau,
Tulegen M. Seilkhanov, Yurii V. Gatilov

 


Keywords


diastereomers; methanobenzo[g]thiazolo[2,3-d][1,3,5]oxadiazocines; ylidenes, antidiabetic activity; NMR spectroscopy; X-ray structural analysis

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