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SYNTHESIS AND ANTIOXIDANT ACTIVITY OF SOME NEW N-ALKYLATED PYRAZOLE-CONTAINING BENZIMIDAZOLES

Mahesh Bellam, Mohan Gundluru, Santhisudha Sarva, Sridevi Chadive, Vasudeva Reddy Netala, Vijaya Tartte, Suresh Reddy Cirandur
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Abstract


A series of new N-substituted pyrazole-containing benzimidazoles was synthesized starting from 1,2-diaminobenzene and pyrazole-
4-carbaldehyde in good yield. Antioxidant activity of all title compounds was assessed using 2,2-diphenyl-1-picrylhydrazyl and
hydrogen peroxide assays. Some of the synthesized compounds having benzyl substituent at the imidazole nitrogen exhibited good
activity in both assays.


Keywords


benzimidazole; 2,2-diphenyl-1-picrylhydrazyl; hydrogen peroxide; pyrazole; zinc chloride; antioxidant activity

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