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PD-CATALYZED COUPLING REACTION OF 6-HYDROXY- 2-(PROP-2-YN-1-YLSULFANYL)PYRIMIDIN-4(1H)-ONE WITH ARYL IODIDES: EFFICIENT SYNTHESES OF NEW 3-BENZYLTHIAZOLO[3,2-A]PYRIMIDINONES

Ali Keivanloo, Mohammad Bakherad, Taraneh Shahani, Amir Hossein Amin
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Abstract


An efficient synthetic protocol was developed for the preparation of 3-benzyl-7(5)-hydroxy-5(7)H-[1,3]thiazolo[3,2-a]pyrimidin-
5(7)ones from 6-hydroxy-2-(prop-2-yn-1-ylsulfanyl)pyrimidin-4(1H)-one and aryl iodides in the presence of Pd–Cu complex catalyst. This one-pot process provides a simple and direct method for the synthesis of new thiazolo[3,2-a]pyrimidinones in good to high yields.

 

 



Keywords


aryl iodide; propargyl bromide; thiazolo[3,2-a]pyrimidine; thiobarbituric acid; Pd-catalyzed reactions

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Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv