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SYNTHESIS AND CYTOTOXICITY OF AMINOMETHYLSELENOPHENO[3,2-b]THIOPHENE SULFONAMIDES

Павел Арсенян, Кира Рубина, Илона Домрачева
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Abstract


The reaction of 5-[(aminomethyl)ethynyl]thiophene-2-sulfonamides with in situ generated selenium(IV) chloride was used to synthesize  5-aminomethyl-substituted 6-chloroselenopheno[3,2-b]thiophene-2-sulfonamides. The cytotoxicity of these compounds was studied against НТ1080 (human fibrosarcoma), MH-22A (mouse hepatoma), CCL-8 (mouse sarcoma), MES-SA (human uterine sarcoma), MCF-7 (estrogen receptor-positive human breast adenocarcinoma) cell lines, as well as the normal NIH 3T3 cell line (mouse fibroblasts).

Authors: Pavel Arsenyan*, Kira Rubina, Ilona Domracheva


Keywords


selenium; selenophene; sulfonamide; thiophene; cytotoxicity; electrophilic addition; intramolecular cyclization

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