ALKYLATION OF 2-(2,4-DICHLOROPHENYL)-3-CYANO-6-METHYL-4-(1<i>H</i>-1,2,4-TRIAZOL-1-YL)METHYLPYRIDINE AT THE METHYLENE GROUP

Authors

  • Yan Zhu State Key Lab of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry
  • Zhengyan Cai State Key Lab of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry
  • Qun Hao State Key Lab of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry
  • Weicheng Zhou State Key Lab of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry

DOI:

https://doi.org/10.1007/3360

Keywords:

activated methylene compounds, alkyl halides, phenylpyridines, structure–reactivity relationships

Abstract

The reactivity of the 1-triazolyl- and 1-imidazolyl-substituted methylene groups at position 4 of pyridine ring towards alkyl halides is described. Nitrogen heterocycles attached to the methylene group, as well as a 3-cyano group effectively promoted the alkylation, offering a convenient method for constructing structurally diverse molecules that may present pharmaceutical interest.

Author Biographies

Yan Zhu, State Key Lab of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry

Zhengyan Cai, State Key Lab of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry

Qun Hao, State Key Lab of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry

Weicheng Zhou, State Key Lab of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry

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Published

2016-09-08

Issue

Vol. 52 No. 8 (2016)

Section

Original Papers