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ALKYLATION OF 2-(2,4-DICHLOROPHENYL)-3-CYANO-6-METHYL-4-(1H-1,2,4-TRIAZOL-1-YL)METHYLPYRIDINE AT THE METHYLENE GROUP

Yan Zhu, Zhengyan Cai, Qun Hao, Weicheng Zhou
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Abstract


The reactivity of the 1-triazolyl- and 1-imidazolyl-substituted methylene groups at position 4 of pyridine ring towards alkyl halides is described. Nitrogen heterocycles attached to the methylene group, as well as a 3-cyano group effectively promoted the alkylation, offering a convenient method for constructing structurally diverse molecules that may present pharmaceutical interest.


Keywords


activated methylene compounds; alkyl halides; phenylpyridines; structure–reactivity relationships

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