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MICHAEL ADDITION TO UNPROTECTED 3-(2-NITROVINYL)INDOLES UNDER THE CONDITIONS OF MICROWAVE SYNTHESIS

Александр В. Аксенов, Николай А. Аксенов, Антон А. Скоморохов, Инна В. Аксенова, Георгий Д. Грязнов, Леонид Г. Воскресенский, Михаил А. Рубин
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Abstract


A novel highly efficient preparative method for the synthesis of substituted indoles using conjugate addition of nucleophiles to 3-(2-nitrovinyl)indoles has been developed. The addition of nucleophiles generated in the presence of a base from CH acids was investigated. The studied reactions proceed quickly and smoothly under the conditions of microwave activation and do not require protection of the indole nitrogen atom.

Authors: Alexander V. Aksenov*, Nikolai A. Aksenov, Anton A. Skomorokhov, Inna V. Aksenova, Georgii D. Gryaznov, Leonid G. Voskressensky, Michael A. Rubin*

 


Keywords


indole; nitroalkenes; addition; Michael reaction

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