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STUDY ON THE SCALE-UP OF PHASE-TRANSFER-CATALYZED AZO COUPLING REACTIONS IN FLOW REACTORS

Faith Akwi, Paul Watts
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Abstract


We report the first systematic study on the channel size effect in various microreactor systems on the efficiency of phase-transfer-catalyzed azo coupling reactions. The optimum scaled-up channel diameter was 0.5 mm, which facilitated the synthesis of diazo compounds in high yields.

 


Keywords


heterocycles; azo coupling; flow chemistry; microreactors

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