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A SIMPLE SYNTHESIS OF 3,4-DIHYDROBENZO[F]QUINOXALIN-6(2H)-ONE DERIVATIVES SUBSTITUTED IN THE RING B

Vicente Castro-Castillo, Cristian Suarez-Rozas, Sebastian Simpson, Andres Barriga-Gonzalez
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Abstract


We followed a simple, inexpensive, and efficient route to synthesize a series of 3,4-dihydrobenzo[f]quinoxalin-6(2H)-one derivatives substituted in the ring B, with the expectation that this scaffold might exhibit antineoplastic activity. 5-Chlorobenzo[f]quinoxalin-6-yl- acetate and 4-benzylbenzo[f]quinoxalin-6(4H)-one were obtained for the first time.


Keywords


acetamide derivatives; 3,4-dihydrobenzo[f]quinoxalin-6(2H)-ones; 1,4-naphthoquinones; cyclization reaction; nucleophilic substitution.

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