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SYNTHESIS OF DERIVATIVES OF PYRANO[3,4-c][1,2,4]TRIAZOLO[4,3-a]PYRIDINE AND 8-(PYRAZOL-1-YL)PYRANO[3,4-c]PYRIDINE THROUGH PYRIDINE RING REARRANGEMENT

Ерванд Г. Пароникян, Шушаник Ш. Дашян, Нуне С. Минасян, Грачя М. Степанян, Армен Г. Айвазян, Рафаел А. Тамазян
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Abstract


A method has been developed for the synthesis of 8-hydrazino derivatives of pyrano[3,4-с]pyridines on the basis of pyridine ring recyclization. New tricyclic heterocyclic systems, pyrano[3,4-с][1,2,4]triazolo[4,3-а]pyridines and 8-(pyrazol-1-yl)pyrano[3,4-с]pyridines, were synthesized from 8-hydrazino derivatives of pyrano[3,4-с]pyridines. The presence of intermolecular hydrogen bonds in 6-[(4-chlorophenyl)amino]-8-(3,5-dimethyl-1H-pyrazol-1-yl)-3,3-dimethyl-3,4-dihydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile was proved by X-ray structural analysis. The antimicrobial and antitumor activity of the obtained compounds were studied.

 

Authors: Ervand G. Paronikyan, Shushanik Sh. Dashyan*, Nune S. Minasyan, Grachya M. Stepanyan, Armen G. Ayvazyan, Rafael A. Tamazyan


Keywords


8-(пиразол-1-ил)пирано[3,4-с]пиридины; пирано[3,4-c]пиридины; триазоло[4,3-a]пиридины; антимикробная и противоопухолевая активность; перегруппировка

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