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PREPARATION OF BENZIMIDAZOLE N-OXIDES BY A TWO-STEP CONTINUOUS FLOW PROCESS

Fabrizio Politano, Elba I. Buján, Nicholas E Leadbeater

Abstract


A continuous flow process for the synthesis of nitrobenzimidazole N-oxides from 2,6-dinitrochlorobenzene and amines or amino acids is reported. The process, performed in a two-step sequence, is faster than previously reported batch processes and avoids some of the isolation and purification steps.

 


Keywords


benzimidazoles; N-oxides; cyclization; flow chemistry; green chemistry; nucleophilic aromatic substitution

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