FACILE ONE-POT MULTICOMPONENT SYNTHESIS OF 1<i>H</i>-PYRAZOLO[3,4-<i>b</i>]QUINOLINES USING L-PROLINE AS A CATALYST

Authors

  • Hemant Hedge Department of Chemistry, Manipal Institute of Technology, Manipal, Karnataka 576104
  • Nitinkumar S. Shetty Department of Chemistry, Manipal Institute of Technology, Manipal, Karnataka 576104

DOI:

https://doi.org/10.1007/3548

Keywords:

Pyrazolo[3, 4-b]quinolines, organocatalyst, L-proline, multicomponent reaction, one-pot synthesis

Abstract

An efficient protocol for the synthesis of a new series of 1H-pyrazolo[3,4-b]quinolines has been described. The target compounds have been synthesized by one-pot multicomponent reaction of aniline, aromatic aldehydes, and 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one using L-proline as an organocatalyst. Structural diversity and high yields of products, broad scope of aromatic aldehydes, simple operation, and short reaction times have been demonstrated as the advantages of the developed synthetic approach.

Published

2017-10-03

Issue

Section

Original Papers