Open Access Open Access  Restricted Access Subscription Access

A NEW ROUTE TO HIGHLY SUBSTITUTED THIENO[2,3-b]PYRIDINES VIA CASCADE HETEROCYCLIZATION OF 2-ACYL-1,1,3,3-TETRACYANOPROPENIDE SALTS

Arthur Grigor'ev, Sergey Karpov, Yakov Kayukov, Oleg Nasakin, Iuliia Gracheva, Victor Tafeenko
Cover Image

Abstract


2-Acyl-1,1,3,3-tetracyanopropenides undergo cascade heterocyclization under the action of mercaptoacetic esters, leading to the formation of new 3,6-diamino-4-aroyl-5-cyanothieno[2,3-b]pyridine-2-carboxylates. The fast and convenient synthetic way to highly substituted thieno[2,3-b]pyridine scaffold is described.


Keywords


organic nitriles; tetracyanopropenides; thieno[2,3-b]pyridines; cyano group

Full Text: PDF Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv