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SYNTHESIS OF 5-(PYRAZOL-1-YL)-1,2,3-THIADIAZOLES

Ольга А. Высокова, Татьяна А. Калинина, Марина А. Токарева, Татьяна А. Поспелова, Татьяна В. Глухарева, Юрий Ю. Моржерин
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Abstract


A method is proposed for the synthesis of ethyl 5-(3-aryl-4-formyl-1H-pyrazol-1-yl)-1,2,3-thiadiazole-4-carboxylates by a reaction of acetophenone (4-ethoxycarbonyl-1,2,3-thiadiazol-5-yl)hydrazones with a Vilsmeier–Haack complex. The obtained heterocyclic assemblies provide interesting substrates for further modification and study of biological activity.

Authors: Olga A. Vysokova, Tatiana A. Kalinina, Marina A. Tokareva, Tatiana A. Pospelova, Tatiana V. Glukhareva*, Yuri Yu. Morzherin

 


Keywords


гетероциклические ансамбли; гидразоны ацетофенонов; 5-(пиразол-1-ил)-1,2,3-тиадиазолы; пиразолы; 1,2,3-тиадиазолы; реакция Вильсмайера–Хаака

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