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TETRACHLOROSILANE AND ZINC CHLORIDE AS A BINARY REAGENT FOR THE PREPARATION OF 2-AMINO-6-CHLOROPYRIDINE-3,5-DICARBONITRILE DERIVATIVES

Ahmed Mohamed Sheta, Saad S. Elmorsy, Mohammad M. A. Mashaly, Samy B. Said
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Abstract


A green one-pot method for efficient synthesis of 2-amino-6-chloropyridine-3,5-dicarbonitrile derivatives was developed, based on stirring of various aldehydes and malononitrile with tetrachlorosilane and zinc chloride under solvent-free conditions at room temperature for 3–10 h. The effects of zinc chloride and the reaction conditions were studied. Compounds were characterized by X-ray analysis and NMR spectroscopy.


Keywords


malononitrile; pyridine; tetrachlorosilane; zinc chloride; one-pot synthesis.

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