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SYNTHESIS OF 1-TETRAZOLYL-SUBSTITUTED 2,3,4,9-TETRAHYDRO-1H-β-CARBOLINES AND THEIR TRANSFORMATIONS INVOLVING ACTIVATED ALKYNES

Леонид Г. Воскресенский, Александр A. Титов, Реза Самавати, Максим С. Кобзев, Виктор Н. Хрусталев, Хиеу Чыонг Хонг, Тует Ань Данг Тхи, Туен Нгуен Ван, Елена А. Сорокина, Алексей В. Варламов
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Abstract


1-Tetrazolyl-substituted tetrahydro-β-carbolines undergo a reaction with activated alkynes (acetylacetylene, methyl propiolate, and dimethyl acetylenedicarboxylate) over 4–8 days in MeOH or 1 day in CF3CH2OH with the formation of multicomponent mixtures, from which spiro[indole-3,4'-pyridines] were isolated chromatographically. Additionally, two azocino[5,4-b]indoles were isolated from methyl propiolate and acetylacetylene reactions.

Authors: Leonid G. Vosskresensky, Alexander A. Titov, Reza Samavati1, Maxim S. Kobzev, Pavel V. Dorovatovskii, Victor N. Khrustalyev, Hieu Chuong Hong, Tuet An Dang Thi,
Tuyen Nguyen Van, Elena A. Sorokina, Alexey V. Varlamov

 


Keywords


acetylacetylene; azocinoindoles; dimethyl acetylenedicarboxylate; methyl propiolate; spiro[indole-3,4'-pyridines]; tetrazolyl-substituted tetrahydro-β-carbolines

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