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SYNTHESIS OF NEW 4-AMINO-SUBSTITUTED 7-IMINOPYRIDO[2,3-d]PYRIMIDINES

Анна Н. Зинченко, Любовь В. Музычка, Игорь И. Билецкий, Олег Б. Смолий
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Abstract


The reaction of 4,6-dichloropyrimidine-5-carbaldehyde with cyanomethyltriphenylphosphonium chloride gave (2Е)-3-(4,6-dichloropyrimidin-5yl)acrylonitrile, which was further used for the preparation of 4,6-diamino-substituted pyrimidinylacrylonitrile derivatives, capable of intramolecular cyclization with the formation of new 4-amino-substituted 7-iminopyrido[2,3-d]pyrimidines. Performing the reaction with 4-amino-6-chloropyrimidine-5-carbaldehyde led to 7-amino-4-chloropyrido[2,3-d]pyrimidine, a promising intermediate for the synthesis of pyrido[2,3-d]pyrimidine-4,7-diamines.

Authors: Anna N. Zinchenko, Lyubov V. Muzychka, Igor I. Biletskii, Oleg B. Smolii

 


Keywords


4,6-dichloropyrimidine-5-carbaldehyde; 7-iminopyrido[2,3-d]pyrimidines; pyrido[2,3-d]pyrimidine-4,7-diamine; cyclization; Wittig reaction

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