SYNTHESIS OF NEW 4-AMINO-SUBSTITUTED 7-IMINOPYRIDO[2,3-<i>d</i>]PYRIMIDINES
DOI:
https://doi.org/10.1007/3600Keywords:
4, 6-dichloropyrimidine-5-carbaldehyde, 7-iminopyrido[2, 3-d]pyrimidines, pyrido[2, 3-d]pyrimidine-4, 7-diamine, cyclization, Wittig reactionAbstract
The reaction of 4,6-dichloropyrimidine-5-carbaldehyde with cyanomethyltriphenylphosphonium chloride gave (2Е)-3-(4,6-dichloropyrimidin-5yl)acrylonitrile, which was further used for the preparation of 4,6-diamino-substituted pyrimidinylacrylonitrile derivatives, capable of intramolecular cyclization with the formation of new 4-amino-substituted 7-iminopyrido[2,3-d]pyrimidines. Performing the reaction with 4-amino-6-chloropyrimidine-5-carbaldehyde led to 7-amino-4-chloropyrido[2,3-d]pyrimidine, a promising intermediate for the synthesis of pyrido[2,3-d]pyrimidine-4,7-diamines.
Authors: Anna N. Zinchenko, Lyubov V. Muzychka, Igor I. Biletskii, Oleg B. Smolii
