SYNTHESIS AND CHEMICAL PROPERTIES OF NEW DERIVATIVES OF 3a',6a'-DIHYDRO-2'<i>H</i>-SPIRO[INDOLE-3,1'-PYRROLO[3,4-<i>c</i>]PYRROLE]2,4',6'(1<i>H</i>,3'<i>H</i>,5'<i>H</i>)-TRIONE

Authors

  • Т. Л. Павловская State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine;
  • Р. Г. Редькин State Institution "V. J. Danilevsky Institute of Problems of Endocrine Pathology of the Academy of Medical Sciences of Ukraine"
  • Ф. Г. Яременко State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine; State Institution "V. J. Danilevsky Institute of Problems of Endocrine Pathology of the Academy of Medical Sciences of Ukraine"
  • С. В. Шишкина State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine
  • О. B. Шишкин State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine; V. N. Karazin Kharkiv National University
  • В. И. Мусатов State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine
  • В. В. Липсон State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine; State Institution "V. J. Danilevsky Institute of Problems of Endocrine Pathology of the Academy of Medical Sciences of Ukraine"; V. N. Karazin Kharkiv National University

DOI:

https://doi.org/10.1007/362

Keywords:

α-amino acids, isatins, maleimides, acylation, alkylation, 1, 3-cycloaddition, nitrosation

Abstract

A series of new 3a',6a'-dihydro-2'H-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,4',6'(1H,3'H,5'H)-triones has been synthesized by cycloaddition of azomethine ylides, obtained from isatins and acyclic aliphatic and sulfur-containing α-amino acids, to maleimides. The direction of the cycloaddition was determined and the chemical properties of the obtained spiro products were examined.

Authors: T. L. Pavlovskaya, R. G. Red'kin, F. G. Yaremenko, S. V. Shishkina, O. V. Shishkin, V. I. Musatov, and V. V. Lipson

English Translation in Chemistry of Heterocyclic Compounds, 2013, 49 (6), pp 882-896

http://link.springer.com/article/10.1007/s10593-013-1322-1

Author Biographies

Т. Л. Павловская, State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine;

Татьяна Леонидовна Павловская

Р. Г. Редькин, State Institution "V. J. Danilevsky Institute of Problems of Endocrine Pathology of the Academy of Medical Sciences of Ukraine"

Руслан Григорьевич Редькин

Ф. Г. Яременко, State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine; State Institution "V. J. Danilevsky Institute of Problems of Endocrine Pathology of the Academy of Medical Sciences of Ukraine"

Федор Георгиевич Яременко

Лаборатория синтеза гормоноподобных соединений

С. В. Шишкина, State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine

ГНУ "НТК "Институт монокристаллов" НАН Украины

О. B. Шишкин, State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine; V. N. Karazin Kharkiv National University

Олег Валерьевич Шишкин

В. И. Мусатов, State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine

Владимир Иванович Мусатов

В. В. Липсон, State Scientfic Institution "Institute for single crystals" of National Academy of Sciences of Ukraine; State Institution "V. J. Danilevsky Institute of Problems of Endocrine Pathology of the Academy of Medical Sciences of Ukraine"; V. N. Karazin Kharkiv National University

Виктория Викторовна Липсон

Зав отдела медицинской химии, д.х.н.

Downloads

Published

2013-06-13

Issue

No. 6 (2013)

Section

Original Papers