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SYNTHESIS OF NEW HETEROCYCLIC DEHYDROABIETYLAMINE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY

Ксения С. Ковалева, Ольга И. Яровая, Андрей В. Шернюков, Владимир В. Зарубаев, Анна А. Штро, Яна Р. Оршанская, Нариман Ф. Салахутдинов
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Abstract


New derivatives of dehydroabietylamine were obtained by transformation of primary amino group to pyrrolidine, piperidine, azepane, morpholine, isoindoline, and pyrrole heterocycles. The obtained compounds were tested for antiviral activity against influenza A/California/07/09 (H1N1)pdm09 strain, as well as the activity against some types of bacteria and fungi.

Authors: K. S. Kovaleva, O. I. Yarovaya, A. V. Shernyukov, V. V. Zarubaev, A. A. Shtro, Y. R. Orshanskaya, N. F. Salakhutdinov

 


Keywords


dehydroabietylamine; antibacterial activity; antiviral activity; natural compounds

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