Open Access Open Access  Restricted Access Subscription Access

PREPARATION AND BIOLOGICAL PROPERTIES OF 2-THIO-CONTAINING PYRIMIDINES AND THEIR CONDENSED ANALOGS

Oleksii Y. Voskoboynik, Oleksandra S. Kolomoets, Galina G. Berest, Inna S. Nosulenko, Yuliya V. Martynenko, Sergiy I. Kovalenko
Cover Image

Abstract


The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions. The literature data analysis shows that the title compounds possess diverse biological activities, such as antioxidant, radioprotective, analgesic, antiinflammatory, antihypertensive, anxiolytic, anamnestic, anticonvulsant, antimicrobial, fungicidal, herbicidal, antiviral, and anticancer.

Keywords


condensed pyrimidines; thioxopyrimidines; biological activity; synthesis

Full Text: PDF Supplementary File(s): None


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv