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SYNTHESIS AND BIOLOGICAL ACTIVITY OF HETEROCYCLIC BORNEOL DERIVATIVES

Anastasiya S. Sokolova, Olga I. Yarovaya, Anna A. Shtro, Marina S. Borisova, Ekaterina A. Morozova, Tatyana G. Tolstikova, Vladimir V. Zarubaev, Nariman F. Salakhutdinov
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Abstract


A series of novel heterocyclic derivatives of (–)-borneol has been prepared by the interaction of (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 2-chloroacetate and (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 3-chloropropanoate with different N- and S-nucleophiles. The obtained products were screened for antiviral, antiulcer, and analgesic activity.

 


Keywords


1H-benzimidazole-2-thiol; benzoxazole-2-thiol; benzthiazole-2-thiol; (–)-borneol; analgesic activity; antiulcer activity; antiviral activity

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