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HETEROCYCLES AS CLASSICAL AND NONCLASSICAL RING B ISOSTERS IN COMBRETASTATIN A-4

Nikolay A. Zefirov, Olga N. Zefirova
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Abstract


The minireview provides a survey of combretastatin A-4 analogs, obtained by isosteric replacement of 3-hydroxy-4-methoxyphenyl ring (ring B) with various heterocyclic systems. The basic synthetic approaches and structure–activity relationships are summarized.


Keywords


Combretastatin A-4; heterocycles; structure–activity relationship; isosteric replacement; cytotoxicity

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