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GREEN SYNTHESIS OF INDOL-2-ONE DERIVATIVES FROM N-ALKYLISATINS IN THE PRESENCE OF KF/CLINOPTILOLITE NANOPARTICLES

Faramarz Rostami-Charati, Zinatossadat Hossaini, Rezvaneh Rostamian, Mehdi Ghambarian, Afshin Zamani, Mahshid Abdoli
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Abstract


KF/clinoptilolite nanoparticles were used as an effective heterogeneous catalyst for the synthesis of spiro[indole-3,2'-pyran] derivatives via three-component reactions of N-alkylisatins, 1,3-dicarbonyl compounds, and electron-deficient acetylenic compounds under solventfree conditions at 80°C. The present protocol has significant advantages, such as high yields, easy purification, and low environmental impact.


Keywords


activated acetylenic compounds; N-alkylisatin; 1,3-dicarbonyl compounds; KF/clinoptilolite nanoparticles; green synthesis

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