FACILE ONE-POT SYNTHESIS OF PYRAZOLO[1,5-<i>a</i>]PYRAZINE SCAFFOLD

Authors

  • O. V. Zaremba National University of Pharmacy
  • N. Yu. Gorobets Department of Chemistry of Heterocyclic Compounds, SSI "Institute for Single Crystals", National Academy of Science of Ukraine
  • S. S. Kovalenko National University of Pharmacy
  • O. G. Drushlyak National University of Pharmacy
  • O. Yu. Grevtsov National University of Pharmacy
  • S. M. Kovalenko National University of Pharmacy

DOI:

https://doi.org/10.1007/366

Keywords:

azolocarboxamidoacetals, 6, 7-dihydropyrazolo[1, 5-a]pyrazin-4(5H)-one, 2, 2-dimethoxyethanamine, pyrazole-3-carboxilic acid, pyrazolo[1, one-pot reaction

Abstract

A series of novel pyrazolo[1,5-a]pyrazine derivatives has been synthesized using facile one-pot three-step protocol starting from pyrazole-3-carboxilic acids. The process occurs via amide formation with consequent pyrazine ring closure, hydrolysis, and dehydration. 7-Hydroxy-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one and 7-methoxy-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one have been isolated as intermediate compounds.

Also published in Chemistry of Heterocyclic Compounds, 2013, 49 (6), pp 915-921

http://link.springer.com/article/10.1007/s10593-013-1326-x

Author Biographies

O. V. Zaremba, National University of Pharmacy

Oleg Viktorovich Zaremba

N. Yu. Gorobets, Department of Chemistry of Heterocyclic Compounds, SSI "Institute for Single Crystals", National Academy of Science of Ukraine

Nikolay Yuriyovich Gorobets

S. S. Kovalenko, National University of Pharmacy

Svitlana Sergiyivna Kovalenko

O. G. Drushlyak, National University of Pharmacy

Oleksandr Grigorievich Drushlyak

O. Yu. Grevtsov, National University of Pharmacy

Oleksandr Yuriyovich Grevtsov

S. M. Kovalenko, National University of Pharmacy

Sergiy Mikolayovich Kovalenko

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Published

2013-06-13

Issue

No. 6 (2013)

Section

Original Papers