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NEW TRIFLUOROMETHYL-SUBSTITUTED HETEROCYCLES BY MULTICOMPONENT REACTIONS OF SILOXYCYCLOPROPANES

Daniel Gladow, Deborah Senf, Jelena Wiecko, Dieter Lentz, Reinhold Zimmer, Hans-Ulrich Reissig
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Abstract


Multicomponent reactions of ethyl 1-trifluoromethyl-2-(trimethylsilyloxy)cyclopropanecarboxylate, isonitriles, and either 2-aminopyridine or amino acids provided imidazo[1,2-a]pyridines or γ-lactams, respectively. This access to trifluoromethyl-substituted heterocycles demonstrates again that siloxycyclopropanes can serve as hidden functionalized aldehydes and that this type of donor–acceptor-substituted cyclopropanes is particularly versatile.

 


Keywords


cyclopropanes; isonitriles; amino acids; pyridines; γ-lactams; multicomponent reactions

Full Text: PDF Supplementary File(s): Supporting information (486KB)


 

 

Latvian Institute of Organic Synthesis - Aizkraukles iela, 21, Riga, LV-1006, Latvia - hgs@osi.lv