NEW TRIFLUOROMETHYL-SUBSTITUTED HETEROCYCLES BY MULTICOMPONENT REACTIONS OF SILOXYCYCLOPROPANES

Authors

  • Daniel Gladow
  • Deborah Senf
  • Jelena Wiecko
  • Dieter Lentz
  • Reinhold Zimmer
  • Hans-Ulrich Reissig Institut für Chemie und Biochemie, Freie Universität Berlin Takustraße 3, D-14195 Berlin, Germany

DOI:

https://doi.org/10.1007/3674

Keywords:

cyclopropanes, isonitriles, amino acids, pyridines, γ-lactams, multicomponent reactions

Abstract

Multicomponent reactions of ethyl 1-trifluoromethyl-2-(trimethylsilyloxy)cyclopropanecarboxylate, isonitriles, and either 2-aminopyridine or amino acids provided imidazo[1,2-a]pyridines or γ-lactams, respectively. This access to trifluoromethyl-substituted heterocycles demonstrates again that siloxycyclopropanes can serve as hidden functionalized aldehydes and that this type of donor–acceptor-substituted cyclopropanes is particularly versatile.

 

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Published

2017-05-02

Issue

Vol. 53 No. 4 (2017): Multicomponent reactions in the synthesis of heterocycles

Section

Original Papers