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FACILE CONSECUTIVE THREE-COMPONENT SYNTHESIS OF 3,5-DISUBSTITUTED ISOXAZOLES

Christina Görgen, Thomas J. J. Müller
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Abstract


3,5-Di(hetero)aryl-substituted isoxazoles can be rapidly synthesized in a one-pot fashion by a consecutive three-component alkynylation–cyclization sequence starting from (hetero)aroyl chloride, alkynes, and sodium azide/acetic acid under copper-free palladium catalysis as exemplified by 9 different products.

 


Keywords


alkynes; azidation; copper-free alkynylation; cyclization; isoxazoles; multicomponent reactions

Full Text: PDF Supplementary File(s): Supporting information (812KB)


 

 

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