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SYNTHESIS OF NEW PYRROLO[2,1-a]PHTHALAZINE DERIVATIVES VIA MULTICOMPONENT REACTION OF PHTHALAZINE WITH 1,1-DICYANOALKENES AND ALKYL ISOCYANIDES

Maxim A. Mironov, Iliya D. Shulepov, Ksenia V. Kozhikhova, Maria N. Ivantsova, Maria I. Tokareva
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Abstract


Multicomponent reactions between phthalazine, alkyl isocyanides, and 1,1-dicyanoalkenes in acetonitrile–water mixture produced high yields of substituted pyrrolo[2,1-a]phthalazines, which were converted upon treatment with 10% hydrochloric acid to pyrrolo[2,1-a]phthalazines unsubstituted at position 1. As a result, a range of new pyrrolo[2,1-a]phthalazine derivatives have been synthesized by this one-pot approach.

 


Keywords


phthalazine, multicomponent reaction, isocyanides, decarboxylation, one-pot synthesis

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