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SYNTHESIS OF SEVEN-MEMBERED NITROGEN HETEROCYCLES THROUGH THE UGI MULTICOMPONENT REACTION

Luca Banfi, Andrea Basso, Chiara Lambruschini, Lisa Moni, Renata Riva
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Abstract


This paper reviews all the syntheses of 7-membered nitrogen heterocycles that are based on the Ugi multicomponent reaction. Different systems may be obtained in a diversity-oriented manner employing three general strategies: i) intramolecular Ugi reaction; ii) Ugi reaction followed by cyclization involving one additional functional group; iii) Ugi reaction followed by cyclization involving two additional functional groups.

Keywords


azepines; benzazepines; benzodiazepines; diazepines; oxazepines; thiazepines; multicomponent reactions; Ugi reaction

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